Pros and Cons of Donating Plasma

Plasma is a yellowish liquid made up of proteins, salts, sugars and other materials. It’s found in blood plasma and makes up 55% of blood volume. Plasma helps transport nutrients through the body, help control bleeding and fight infection. It also plays an important role in maintaining a healthy immune system. Plasma donation is something that most people may think they can’t do because they’re not old enough or have health issues that could make it dangerous for them to donate their blood. But there’s no age limit to donating plasma so you can donate as long as your doctor gives you clearance due to any current or past medical condition(s). It usually takes about one hour from start to finish including registration time which is done before arriving at the plasma center where donation takes place in an outpatient setting (not hospital).

pros and cons of donating plasma


  • Donating plasma is safe and easy. It requires only a few hours of your time, and you can donate frequently if you want to (about every two weeks). The needles used for donating are very thin, so the process doesn’t usually cause any pain or discomfort.
  • Donating plasma can help save lives. Plasma contains proteins that help fight infections, clot blood when needed, carry oxygen from the lungs to tissues throughout the body, regulate body temperature when we’re cold or hot, etc. Because of this, donated plasma is often used for patients with chronic conditions like heart disease or cancer; it’s not just used by burn victims anymore!

Saves lives

It’s a common misconception that donating blood is the only way to help patients with diseases like hemophilia or immune system disorders. While it’s true that less than 1% of people in the United States are eligible to donate blood, there are many others who can donate plasma but not whole blood. Donating plasma is safe, effective and easy for both donors and patients. It’s also an opportunity for you to give back to your community and make an impact on those around you.

Helps patients with chronic conditions

Plasma is very important in transfusion medicine. It helps patients with chronic conditions, such as immune system disorders, blood disorders and blood pressure disorders.

In addition to the benefits of donating plasma for transfusion medicine, it has many other applications in biomedical research and development.

Regular source of income

  • Donating plasma is a regular source of income.
  • You can donate plasma on a weekly or monthly basis, depending on your schedule and how much money you want to make.

Increases plasma supply

Donating plasma is a great way to help the community because it increases plasma supply for those who need it. Plasma can be used to treat burns, immune system disorders, and blood disorders such as sickle cell disease. In addition, it can be used in research and development on new treatments for cancer and other diseases.

Plasma is also known as the “liquid part” of blood; it contains water and nutrients that help keep tissues healthy. We all lose some plasma every day due to normal body processes like sweating or urination (we pee about a pint every day!). But if we don’t replace this fluid with foods that contain water (like fruits) then we may become dehydrated quickly.

Supports research and development

Donating plasma is a way to help support research and development. Many companies use your plasma for their products, which can in turn help people with chronic conditions.

Donating plasma is a way to help people with chronic conditions who need regular supplies of specific proteins like factor VIII or albumin. These are produced through innovative techniques that rely on human cells (plasma). Your donations will go towards supporting this research and development by helping buy advanced equipment needed to produce these products.

Helps blood disorders

It helps blood disorders by increasing the supply of red blood cells, which carry oxygen to body tissues. It also helps immune system disorders by acting as a source of plasma proteins that can be used in a wide variety of medical procedures. These proteins are used to treat burns, severe cuts and wounds, bleeding disorders such as hemophilia and thrombocytopenia; immune system deficiencies like immunodeficiency virus patients; and organ transplantation patients whose bodies reject the new organ.

Helps immune system disorders

  • Helps the body fight off infections
  • Helps the body fight off diseases
  • Helps the body fight off cancer
  • Helps the body fight off other illnesses

Safe and controlled environment

Although donating plasma is relatively safe and controlled, it is important to note the following risks:

  • Donors must be at least 18 years of age.
  • Donors must be healthy and have a good blood pressure.
  • The donation process can be uncomfortable for some people, but once it’s over, you’ll feel fine — as long as you follow the instructions given by staff for after-care.

Can be done regularly

You can donate plasma as often as twice in a seven-day period. If you donate blood, you’ll need to wait at least 56 days between donations. If you’re returning to the center for your second donation, ask if they have any questions about how much time has passed since your first donation or how much iron and protein levels in your body have changed.

Donating also helps people with chronic conditions who need constant medication and infusions of fluids and nutrients, like patients with multiple sclerosis (MS) or diabetes mellitus type 1 (DM1). Donations are used to make lifesaving treatments such as immune globulin intravenous (IVIG), albumin IVIG therapies, immunoglobulin therapy for primary immunodeficiency diseases, blood clotting factors such as Factor VIII products used in hemophilia A patients; antihemophilic factor products used in hemophilia B patients; factor IX concentrate for treating von Willebrand disease type II; plasmapheresis products used during chemotherapy treatments; filgrastim/pegfilgrastim products that stimulate white cell growth after chemotherapy treatment has ended so they can fight infection more effectively until their own immune system kicks back into gear again; apheresis platelet refills which increase platelet counts temporarily after undergoing an invasive procedure such as surgery or cancer treatment where there is risk of bleeding out due to low platelet counts (eg thrombocytopenia); fresh frozen plasma transfusion therapy; gamma globulin therapy

Minimal discomfort

It’s safe to say that there is minimal discomfort involved in donating plasma. That’s because the way plasma is collected makes the whole process quick and easy. The donor lies on a bed while blood flows through his or her arm into a machine called a centrifuge, which separates out two types of blood cells from the liquid portion known as plasma. Thanks to this process, donors don’t have to go through any needles or vials at all; they just lie back and relax for a few minutes while their blood gets spun around inside the centrifuge!

Improves overall health

  • You can help save lives by donating your plasma. It is a safe and effective way to help others.
  • It also has benefits for you! Plasma donations are a regular source of income, which is especially important if you have an illness or disability that keeps you from working full time. For many donors, the process itself provides a calming effect that helps reduce stress levels and improve overall health. While other types of donation (like blood) are limited in frequency, there are no restrictions on how often someone can donate plasma in most states.*

Reduces disease risk

  • Reduces the risk of cardiovascular disease
  • Reduces the risk of stroke
  • Reduces the risk of diabetes
  • Reduces the risk of cancer (specifically breast, lung and prostate)

Giving back to the community

Giving back to the community is a great way to give something back to society. Many people are unable to afford medical care, and donating plasma can help them out by providing them with much-needed money. You may also enjoy knowing that you’re helping people receive treatment for cancer or other chronic illnesses, increasing their quality of life. In addition, donating plasma regularly can offer many health benefits for you as well!

Increases self-esteem and purpose

Donating plasma can be an important act of altruism, giving you an opportunity to help in the community while also improving your own health. It can also give you a sense of accomplishment and purpose, since you’re doing something that helps others. You may even find that donating plasma regularly will help increase your self-esteem, which is always a bonus!

Sense of accomplishment

Donating plasma is a way to help others, and it can make you feel good about yourself. Donating plasma gives you the sense of purpose and accomplishment that comes from helping others in need of medical treatment. The process is safe and controlled, so there are minimal risks involved, but you should still be aware that some side effects may occur during the donation process. Donating plasma regularly allows you to contribute more blood products to help even more people in need of transfusions or other treatments than what would otherwise be available through blood donations alone.

Minor side effects

  • Minor side effects include headaches, nausea, vomiting and dizziness. These side effects are temporary and can be reduced by drinking plenty of water. The risk of these side effects can be reduced by donating plasma more often.
  • Long term regular donations may cause changes in iron levels or affect the development of your bones. If you have had a blood clot in the past or any other medical conditions that could put you at risk for another blood clot, talk to your doctor before donating plasma regularly or donating too often.

Risk of complications

The most common risks associated with donating plasma are minor side effects, including pain or discomfort at the site of collection; fatigue after donation; and weight loss. The risk of complications from donation is very low, because it is done in a sterile environment and under medical supervision.

There are also some long-term concerns about donating plasma regularly:

  • The body can only make so much blood in a given period of time. Donating too often may compromise the body’s ability to replenish its own supply of red blood cells and platelets (which help stop bleeding). This can cause anemia—a condition where there aren’t enough red blood cells—and an increased risk for infection or illness due to low levels of white blood cells.* Your body needs iron to make new red blood cells. If you donate plasma frequently, your iron stores could become depleted and your hemoglobin level may drop below normal levels.* Dehydration can occur when you don’t drink enough water before or after donating plasma.* Protein metabolism may be affected by frequent donations as well, which could reduce muscle mass over time if not compensated for appropriately through diet or exercise.* High volumes of donor plasma may interfere with the normal functioning of your immune systemIf any symptoms arise following a donation that seem unusual or severe please contact us immediately so we may better understand why this has happened.”

Time commitment

The time commitment is another important factor to consider when deciding whether to donate plasma. Donating plasma takes up to 2 hours and can be done as often as once per week. If you’re interested in donating blood plasma regularly, it’s important that you set aside enough time each week for this procedure and take into account any other obligations (work, family) that might conflict with those appointments.

Temporary discomfort

Temporary discomfort or minor side effects are also possible. These can include:

  • Temporary bruising or discomfort at the site of blood collection
  • Headaches, dizziness, and fatigue from donating too often.

Impact on iron levels

As you donate plasma, you are giving up some of the iron in your blood and taking on some of the plasma that is donated back into your body. Your body will then begin to replace this lost iron as it normally would with food and/or supplements. People who donate frequently may need to increase their intake of iron-rich foods like spinach, kale, beans and lentils in order to maintain good health and prevent anemia from developing.

Impact on hydration

It’s important to drink plenty of water before donating plasma and for several hours afterward. The process can cause dehydration, which can lead to headaches, nausea and dizziness. Drinking water before donating will help minimize these symptoms. After you donate, you should drink one glass of water every hour until your next meal or snack.

Impact on weight

Another impact of donating plasma is the potential to lose weight. In theory, your body burns more calories after donating plasma than it would have otherwise, which means you could potentially lose some weight. However, it’s important to note that any extra weight lost after donating may very well be due to dehydration and an increase in hematocrit (the amount of red blood cells in your blood). If you’ve had a bad experience with donations because they left you feeling tired and hungry afterward, this might be a good reason to reconsider future donations.

Impact on hemoglobin

  • Hemoglobin is the protein in red blood cells that carries oxygen through your body.
  • When you donate plasma, your body makes new red blood cells to replace those that were removed. This means your hemoglobin levels will drop temporarily while you’re donating.
  • If you’re planning to donate repeatedly, your hemoglobin levels may never recover fully and can even become low enough to cause anemia (a condition where there aren’t enough healthy red blood cells).

Impact on blood pressure

Blood pressure is a measure of the force that blood exerts on blood vessel walls. Blood pressure varies throughout your body, with the highest pressures found in parts of the body where it pushes against something hard (such as bones when you are standing). Blood pressure normally rises as you get older and can be affected by many things including diet, exercise, stress and illness.

In plasma donation centres, donors will experience an increase in their systolic (top number) and diastolic (bottom number) blood pressures while donating plasma due to a reduction in volume which happens during collection. This increase in blood pressure has been associated with several health risks such as cardiovascular disease, stroke and heart attack.[1]

Impact on blood volume

Impact on blood volume: You will experience an increase in your blood volume by up to 30% during the donation process. While it is temporary, this increase can cause headaches, dizziness and fainting; therefore, you should be cautious about standing for too long after donating. If you do faint or feel lightheaded after donating plasma, contact a medical professional immediately!

Impact on blood clotting

Another side effect of donating plasma is an increased risk of blood clots. This can be a problem for people with existing conditions such as deep vein thrombosis or pulmonary embolism, which develop when clots form in the body and block circulation. For example, if you have an artificial hip or knee—which are made out of metal—the friction caused by repeated movement has been shown to increase your risk of developing a blood clot.

However, if you have one of these conditions and donate plasma regularly, it may put you at greater risk because the donation process can cause slight trauma to your veins and muscles that could lead to clots forming in those areas as well. You’ll also be lying down for about three hours per session during which time there isn’t much activity going on (apart from talking) so there’s less pressure on your legs—another factor that increases the chances of developing a clot during this time period!

Impact on protein metabolism

Protein metabolism is the process of breaking down proteins into amino acids and then using them to build new proteins. Proteins are made up of smaller molecules called amino acids, which can be used to create various substances such as muscle tissue, organs or enzymes needed for healthy functioning.

The donation process causes a temporary dip in your body’s protein stores (albumin). This means that while your blood levels return to normal within 24 hours after donating plasma, you may experience mild symptoms such as fatigue until those levels return to normal too.

Impact on immune system

The immune system is responsible for fighting off diseases, infections and other threats to our bodies. The more cells in your body that are actively fighting off these threats, the healthier you’ll be. This can help to prevent illnesses like cancer or heart disease later on down the line. It’s also thought that increasing your white blood cell count can make you live longer as well!

Impact on overall health

The most significant negative impact of donating plasma is an increase in iron levels, which can lead to iron overload. Hemoglobin is a protein that carries oxygen in red blood cells, and when it becomes too high, it causes excess iron. Over time, this overload can cause damage to organs and tissues as well as result in organ failure. It can also lead to internal bleeding due to excessive clotting caused by increased platelet production (a protein involved with blood clotting).

Gilbert Peralta, who donated plasma for 20 years before retiring from his job as a lab technician at Uni-Pharma Plasma Services Inc., says he experienced some minor side effects from the procedure during his first few donations but none since then: “I did feel dehydrated after donating,” he says. “But I drank more water afterwards anyway—it’s important not to get dehydrated.”


A donation of plasma is a great way to give back to the community and help people who are suffering from chronic conditions. It also provides you with the opportunity to earn extra income while reducing your risk of developing certain diseases by giving back some of your own blood. This process only requires a few hours out of your day, so it shouldn’t be difficult for anyone looking for an easy way to make some extra cash!